Ryan Hamilton is an American stand-up Comedian who uses observational, sarcastic, and self-deprecating humor. He is known as a clean comedian and his material focuses on his own experiences, including his single life, skydiving, hot air balloons, and his huge smile. He was named one of Rolling Stone’s Five Comics to Watch in 2012, and also has made standout appearances on The Tonight Show Starring Jimmy Fallon, The Late Show with Stephen Colbert, Conan, The Late Late Show, Last Comic Standing, Comedy Central, and Showtime. In 2019, Netflix released his first special, Happy Face, and he opened for Jerry Seinfeld.

Hamilton has embraced being considered a "clean" comedian in comparison to many of his colleagues. "Yeah, I guess at a certain point it becomes intentional," he told St Louis Magazine in 2019. "It's always the way I've performed. It's authentic to who I am, so it comes out that way. The comedy from the beginning that I loved and admired and that I looked at as career models were always kind of clean comedians, too."