George Lopez’s multi-faceted career encompasses television, film, standup comedy and late-night television.

Lopez is currently on his standup comedy tour, The Comedy Get Down, with Charlie Murphy, Eddie Griffin, D.L. Hughley, and Cedric the Entertainer in arenas across the country. The comedians also recently wrapped a BET scripted comedy series based on their tour.

Lopez is also starring in his new comedy series, Lopez on TV Land. Starring and produced by Lopez, the series explores how he struggles between his two worlds and crises that are often of his own making. The half hour single camera serialized comedy consists of 12 episodes and has been renewed for a second season.

For two seasons, Lopez hosted Lopez Tonight, a late-night television talk show on TBS, which represented Lopez's return to series television after co-creating, writing, producing and starring in Warner Bros. Television's groundbreaking hit sitcom George Lopez, which ran for six seasons on ABC. George Lopez remains a hit with viewers in syndication on both broadcast stations and cable's Nick at Nite, ranking as one of the top-rated shows on the network and among the top five comedies and top 20 weekly programs in syndication. George Lopez is one of only four off-net comedies to post weekly ratings gains among households from the 2007-'08 to 2008-'09 season.

In 2015, Lopez was seen in the Lionsgate inspirational drama, Spare Parts. Produced by Lopez, the film is based on a true story about four undocumented Mexican-American teenagers from Phoenix who team up to build an underwater robot that wins the national robotics competition. In 2014, Lopez starred in the multi-camera ensemble comedy Saint George on FX, which he co-created.

In 2013, Lopez released his second memoir, I’m Not Gonna Lie And Other Lies You Tell When You Turn 50, where he tells the unabashed and hilarious truth about aging – as only he can.  In 2012, Lopez debuted his third solo stand-up special It’s Not Me, It’s You on HBO. Lopez also voiced animated characters in a string of animated blockbuster films including Rafael in Rioand Rio 2 along with Jamie Foxx, Anne Hathaway and Jesse Eisenberg, Thurman in Escape from Planet Earth opposite Jane Lynch and Sofia Vergara, Grouchy Smurf in The Smurfs 1 and 2, and The Beverly Hills Chihuahua 1, 2, and 3. His other most recent film credits include the box-office hit Valentine's Day  directed by Garry Marshall,  Swing Vote, Henry Poole Is Here and Balls of Fury.

In August 2009, Lopez filmed his second HBO Comedy Special, Tall, Dark and Chicano, which was nominated for a GRAMMY in the category of Best Comedy Album. He headlined his first HBO Comedy Special, America's Mexican, in 2007. Lopez has also performed as part of HBO and TBS's Comic Relief 2006. His acclaimed comedy concert, Why You Crying?, debuted on Showtime in 2004. He released his third standup CD, El Mas Chingon, in 2006, which also earned Lopez a GRAMMY nomination in the category of Best Comedy Album. Prior to that, in 2004, he was nominated for a GRAMMY in the same category for his CD Team Leader. In May 2004, his autobiography, Why You Crying?, entered The New York Times Bestsellers List top 20. The book was co-written by Emmy winning writer and sportscaster Armen Keteyian. Lopez also was the focus of the award-winning documentary Brown is the New Green: George Lopez and the American Dream.

In 2006, Lopez received a star on the Hollywood Walk of Fame. In addition, Time magazine named him one of the 25 Most Influential Hispanics in America, and the Harris Poll named him one of the Top Ten Favorite Television Personalities.